Applicant already as a first author publication. This aim will be performed in close collaboration with Dr. Recommend as Requested R e s our c e Sharing Plans: Independent and competitive OPKA survival of strains expressing 11A and 11E capsule will be compared, and the capacity of purified 11A and 11E PS to inhibit functional antibodies will be determined. Clearly feasible in the environment provided. A week after final immunization, mice will be co-infected NP or IV with both 11Astr and 11Ekan according to optimal protocols determined in aim 3a. Our studies led us to develop ways to accurately measure vaccine-induced antibodies to pneumococcal capsule and also developed a multiplexed opsonophagocytosis assay.
David Briles who specializes in the development and use of murine models of pneumococcal disease. However, pediatric carriage rates have not declined, and there is growing concern that non- PCV-7 serotypes are filling the void left by widespread vaccination This page limit includes the Additional Educational Information required for F30 and F31 applications. Moon Nahm has extensive record of mentoring postdoctoral scientists. Predicted functions and linkage specificities of the products of the Streptococcus pneumoniae capsular biosynthetic loci. Packing your luggage What is NIH already funding on this topic?
This study also begins to validate the use of de-O-acetylated PS in pneumococcal vaccines for disease prevention, a similar strategy to what is being developed against other bacterial pathogens Unacceptable I n c l u s i o n of Women, Minorities and Children: Celebrate arriving at your destination.
Developing the expertise dissertatlon addressing the interface between bacteria and host immunity is invaluable in my training as an effective infectious disease specialist. American Society for Microbiology th General Meeting. To validate the specificity of the method, mAb reactivity to the closely re serotypes 11F, 11B, 11C, and 11D will be evaluated. Letters of recommendations describe a clear thinker and excellent communicator who are passionate about his research, very knowledgeable of the research literature and connect the basic sciences to clinical relevance; an individual who is committed to academic medicine and has the potential to be a leader in the field; among the best and the brightest.
A self-contained gdant of the project.
With your sponsor, set up a phone meeting with the Program Officer PO at NINR who will help answer all your questions and dissertatio you in the submission process. The clinical phase consists of 1. During my rotation in the lab of Dr.
Institutional commitment, sponsor’s research activities and that of surrounding investigators provides a rich environment for training clinician scientists in infectious diseases.
Working backwards grang your deadline, figure out how long each section will take for you to do.
The time at which they become moribund will be recorded. Suzanne Michalek, I helped quantify cytokine production in Toll-like receptor knockout mice, in response to infection with Porphyromonas gingivalis. Bureau of the Census; adjusted annually for changes in the Consumer Price Index; and adjusted by the Secretary for use in all health professions programs.
Genetic basis for the new pneumococcal serotype 6C. The laboratory has weekly meetings where these and other research topics are discussed among graduate students and senior scientists. Sponsors, Collaborators, and Consultants: May 7; Cycle 2: Subsequent studies determined that the subtypes were serologically, structurally and genetically distinct serotypes, 11A and a novel serotype 11E 5, Grang really is a useful adventure for both you and your sponsor!
In a similar manner, 11E conjugated vaccine will be created and administered to mice prior to coinfection.
The 11A serotype appears to be filling the void left by widespread use of rissertation pediatric vaccine in North America and has been associated with greater rates of day mortality relative to other serotypes Generate isogenic 11A and 11E strains for comparative studies.
The candidate is exceptional, has outstanding academic grades, and has a long standing interest in infectious diseases.
The percentage should total for each year. Skip to main content. It should also contain any of the following information that applies to the application: Nahm’s laboratory and in his office. Impact of a new group 6 serotype on pneumococcal vaccines The purpose of the grant is dissertatioh study biochemical, genetic and serological basis of the newly identified pneumococcal serotypes 6C and 6D. Validation of a multiplex pneumococcal serotyping assay with clinical samples.
The Secretary periodically publishes these income levels. Differential effects of pneumococcal vaccines against serotypes 6A and 6C.
Susan Hollingshead and Janet Yother for pneumococcal pathogenesis; David Briles for pneumococcal infection mouse models; Suzanne Michalek and Robin Lorenz for mucosal immunology; Kevin Dyvbig for bacterial xissertation David Pritchard for biochemistry of pneumococcal polysaccharide.